PURPOSE: Complete androgen blockade (CAB) does not prolong overall survival (OS) in patients with castration refractory prostate cancer (CRPC). Although there is variable clinical benefit with second-line hormone manipulation, we do not know which patients might benefit the most. OBJECTIVES: To identify clinical predictors of benefit of complete androgen blockade. MATERIALS AND METHODS: We reviewed the records for 54 patients who received treatment with CAB in the setting of disease progression despite castration. We evaluated progression-free survival (PFS) and OS according to PSA at diagnosis, Gleason scores, age, testosterone level, and duration of prior disease control during castration in first line treatment. RESULTS: Among 54 patients who received CAB, the median PFS was 9 months (CI 4.3-13.7) and OS was 36 months (CI 24-48). We did not find an effect of PSA at diagnosis (p = 0.32), Gleason score (p = 0.91), age (p = 0.69) or disease control during castration (p = 0.87) on PFS or OS. Thirty-four patients subsequently received chemotherapy, with a mean OS of 21 months (CI 16.4-25.5, median not reached). CONCLUSION: Age, Gleason score, PSA at diagnosis and length of disease control with castration did not affect PFS or OS. In the absence of predictors of benefit, CAB should still be considered in CRPC.

CONTEXTUALIZAÇÃO: O teste sentar e alcançar (TSA) usado para medir a flexibilidade lombar e dos músculos isquiotibiais é mais adequado quando usado concomitantemente para avaliar o ângulo da articulação do quadril (AAQ). Acredita-se que o encurtamento do músculo gastrocnêmio afetaria os resultados desse teste. OBJETIVOS: As propostas deste estudo foram correlacionar os resultados do ângulo do quadril e do teste sentar e alcançar e verificar a influência do músculo gastrocnêmio. MÉTODOS: Foi realizado um estudo transversal que envolveu sujeitos saudáveis. Duzentos sujeitos participaram do estudo: 100 homens e 100 mulheres, com idade média de 21,2 anos (DP=1,7). Os materiais usados foram um banco do TSA com uma porta adaptada para avaliar a influência do músculo gastrocnêmio e câmera fotográfica digital. Marcadores cutâneos foram posicionados na espinha ilíaca ântero-superior e trocânter maior. Realizaram-se duas aquisições de imagem: uma com porta fechada (tornozelo em dorsiflexão TD) e outra aberta (tornozelo em flexão plantar - TF). RESULTADOS: Correlação moderada foi encontrada entre AAQ e TSA, tanto para TD como para TF (r=0,48 e 0,44). Os ângulos encontrados com a porta fechada e aberta foram, respectivamente, 95,5º±18,6º e 99,7º±18º (P<0,001). Conclusões: A análise cinemática angular é uma técnica confiável de avaliação do AAQ. A influência do músculo gastrocnêmio foi observada; portanto, sugere-se deixar o tornozelo livre durante a realização do TSA.

BACKGROUND: The sit-and-reach test (SRT) used to measure low back and hamstring flexibility is more adequate when combined with hip joint angle (HJA) measurement. It is supposed that shortening of the gastrocnemius muscle could affect the SRT results. OBJECTIVES: The purposes of the study were to investigate the relationship between the HJA and SRT and to verify the influence of the gastrocnemius. METHODS: This is a cross-sectional study on healthy subjects. Two hundred subjects took part in the study: 100 males and 100 females aged 21.2 years (SD=1.7). The materials used were a sit-and-reach box with an adapted door to evaluate the influence of the gastrocnemius and a digital camera. Skin markers were positioned on the anterior superior iliac spine and greater trochanter. Two pictures were taken in the final position of the test, one with the door closed (with ankle dorsiflexed - DF) and the other with the door opened (with ankle plantarflexed - PF). RESULTS: Moderate correlation was found between the HJA and SRT for DF and PF (r=0.48 e 0.44). The HJA with DF and PF were 95.5º±18.6º and 99.7º±18º (P<0.001), respectively. Conclusions: Angular kinematic analysis is a reliable technique to measure the HJA. The results demonstrated the influence of the gastrocnemius; thus we suggest that the SRT be performed with free ankle joint mobility.